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N Irwin Selected Research

gastric inhibitory polypeptide receptor

2/2015Antagonism of gastric inhibitory polypeptide (GIP) by palmitoylation of GIP analogues with N- and C-terminal modifications improves obesity and metabolic control in high fat fed mice.
8/2013Comparison of the independent and combined metabolic effects of subchronic modulation of CCK and GIP receptor action in obesity-related diabetes.
8/2011Dual modulation of GIP and glucagon action by the low molecular weight compound 4-hydroxybenzoic acid 2-bromobenzylidene hydrazide.
9/2010Active immunization against (Pro(3))GIP improves metabolic status in high-fat-fed mice.
9/2009Evidence for beneficial effects of compromised gastric inhibitory polypeptide action in obesity-related diabetes and possible therapeutic implications.
6/2009Metabolic effects of sustained activation of the GLP-1 receptor alone and in combination with background GIP receptor antagonism in high fat-fed mice.
11/2008(Pro(3))GIP[mPEG]: novel, long-acting, mPEGylated antagonist of gastric inhibitory polypeptide for obesity-diabetes (diabesity) therapy.
4/2008Daily administration of the GIP-R antagonist (Pro3)GIP in streptozotocin-induced diabetes suggests that insulin-dependent mechanisms are critical to anti-obesity-diabetes actions of (Pro3)GIP.
11/2007Comparison of the metabolic effects of GIP receptor antagonism and PYY(3-36) receptor activation in high fat fed mice.
8/2007Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets.
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N Irwin Research Topics

Disease

21Body Weight (Weight, Body)
01/2020 - 03/2004
21Insulin Resistance
01/2020 - 05/2005
18Obesity
01/2019 - 05/2005
10Type 2 Diabetes Mellitus (MODY)
01/2016 - 12/2003
3Glucose Intolerance
06/2009 - 05/2005
2Hyperphagia (Overeating)
02/2011 - 04/2008
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
09/2015
1Hyperinsulinism (Hyperinsulinemia)
11/2008
1Wounds and Injuries (Trauma)
06/2000
1Ganglion Cysts (Ganglion)
06/2000

Drug/Important Bio-Agent (IBA)

20Glucose (Dextrose)FDA LinkGeneric
01/2020 - 03/2004
16Insulin (Novolin)FDA Link
12/2019 - 12/2003
11Peptides (Polypeptides)IBA
01/2019 - 10/2006
11gastric inhibitory polypeptide receptorIBA
02/2015 - 07/2007
9Pro(3)- glucose-dependent insulinotropic polypeptideIBA
02/2015 - 07/2007
9Gastric Inhibitory Polypeptide (Glucose Dependent Insulinotropic Peptide)IBA
02/2015 - 07/2007
6Hormones (Hormone)IBA
01/2019 - 12/2003
6Glucagon-Like Peptide 1 (GLP 1)IBA
01/2018 - 12/2003
5(pGlu-Gln)-CCK-8IBA
08/2013 - 10/2012
4IncretinsIBA
01/2019 - 12/2003
3Biological ProductsIBA
01/2019 - 09/2009
3Glucagon Receptors (Glucagon Receptor)IBA
01/2016 - 12/2013
3LipidsIBA
09/2015 - 07/2007
3Glucagon (Glukagon)FDA Link
12/2014 - 03/2004
3Cholecystokinin (Pancreozymin)IBA
08/2013 - 10/2012
3monomethoxypolyethylene glycol (MPEG)IBA
08/2013 - 11/2008
3Triglycerides (Triacylglycerol)IBA
06/2013 - 09/2009
2xenin 25 (xenin)IBA
01/2020 - 06/2015
2Exenatide (Byetta)FDA Link
12/2019 - 07/2013
2Blood Glucose (Blood Sugar)IBA
12/2014 - 06/2013
2EnzymesIBA
06/2009 - 12/2003
1GastrinsIBA
12/2019
1OxyntomodulinIBA
09/2015
1CholesterolIBA
12/2014
1Cholecystokinin Receptors (Cholecystokinin Receptor)IBA
08/2013
1Gastrointestinal Hormones (Hormones, Gastrointestinal)IBA
06/2013
1MelanocortinsIBA
06/2013
1Streptozocin (Streptozotocin)FDA Link
04/2008
1Peptide Hormones (Polypeptide Hormones)IBA
05/2007
1GhrelinIBA
05/2007
1gastric inhibitory polypeptide (3-42)IBA
10/2006
1Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA
06/2006
1exendin (9-39)IBA
05/2005
1Glucagon-Like Peptide-1 ReceptorIBA
05/2005
1N-pyroglutamyl- glucagon-like peptide-1 (7-36)amideIBA
03/2004
1Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)IBA
12/2003
1GAP-43 Protein (GAP 43 Protein)IBA
06/2000

Therapy/Procedure

3Therapeutics
01/2018 - 11/2008
2Injections
09/2015 - 10/2012
1Punctures
06/2000